Article
Qualitative assessment of previous evidence and an updated meta-analysis confirms lack of association between the ESR1 rs2234693 (PvuII) variant and coronary heart disease in men and women.
Atherosclerosis - 1 Dec 2009
Lluís-Ganella Carla, Lucas Gavin, Subirana Isaac, Escurriol Veronica, Tomás Marta, Sentí Mariano, Sala Joan, Marrugat Jaume, Elosua Roberto
Abstract excerpt
BACKGROUND: Coronary heart disease (CHD) is the leading cause of mortality worldwide. CHD clusters in families but this familial aggregation remains largely unexplained. ESR1 is a candidate gene for CHD although recent meta-analyses of the rs2234693 variant reported inconsistent evidence for association with myocardial infarction (MI) in men. The objectives of this study were to perform a qualitative and a...
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