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Article

BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jul 2009

Kokubo Manabu, Nishio Masahiro, Ribar Thomas J, Anderson Kristin A, West Anne E, Means Anthony R

Abstract excerpt

The Ca(2+)/calmodulin-activated kinases CaMKK2 and CaMKIV are highly expressed in the brain where they play important roles in activating intracellular responses to elevated Ca(2+). To address the biological functions of Ca(2+) signaling via these kinases during brain development, we have examined cerebellar development in mice null for CaMKK2 or CaMKIV. Here, we demonstrate that CaMKK2/CaMKIV-dependent...

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Identifiers

PMID: 19605628
DOI: 10.1523/JNEUROSCI.0040-09.2009
PMCID: PMC2763571

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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