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Article

Staphylococcus aureus agr and sarA functions are required for invasive infection but not inflammatory responses in the lung.

Infection and immunity - 1 Jan 2002

Heyer Geoffrey, Saba Shahryar, Adamo Robert, Rush William, Soong Grace, Cheung Ambrose, Prince Alice

Abstract excerpt

Staphylococcus aureus strains lacking agr- and sarA-dependent gene products or specific MSCRAMM (microbial surface components recognizing adhesive matrix molecules) adhesins were compared for the ability to activate inflammatory responses in the lung. The mutants were evaluated for virulence in a mouse model of pneumonia and by quantifying their ability to stimulate interleukin-8 (IL-8) and granulocyte-macrophage...

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Source

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Identifiers

PMID: 11748173
DOI: 10.1128/IAI.70.1.127-133.2002
PMCID: PMC127645

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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