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Article

Methyltetrahydrofolate reductase C677T gene mutation and hyperhomocysteinemia as a novel risk factor for diabetic nephropathy.

Endocrine - 1 Oct 2009

Ukinc Kubilay, Ersoz Halil Onder, Karahan Caner, Erem Cihangir, Eminagaoglu Selcuk, Hacihasanoglu Arif Bayram, Yilmaz Mustafa, Kocak Mustafa

Abstract excerpt

Hyperhomocysteinemia is a well-defined risk factor for endothelial dysfunction and atherosclerosis. A point mutation (677 C-T) of MTHFR gene results in a significant increase at plasma homocysteine levels. In this study we aimed to evaluate the effects of MTHFR gene mutation and consequent hyperhomocysteinemia on the development of diabetic microvascular complications in comparison with the other defined risk...

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Source

Identifiers

PMID: 19598005
DOI: 10.1007/s12020-009-9218-7

Genes

MTHFR
CRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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