Article
Expanding the detectable HLA peptide repertoire using electron-transfer/higher-energy collision dissociation (EThcD).
Proceedings of the National Academy of Sciences of the United States of America - 25 Mar 2014
Mommen Geert P M, Frese Christian K, Meiring Hugo D, van Gaans-van den Brink Jacqueline, de Jong Ad P J M, van Els Cécile A C M, Heck Albert J R
Abstract excerpt
The identification of peptides presented by human leukocyte antigen (HLA) class I is tremendously important for the understanding of antigen presentation mechanisms under healthy or diseased conditions. Currently, mass spectrometry-based methods represent the best methodology for the identification of HLA class I-associated peptides. However, the HLA class I peptide repertoire remains largely unexplored because...
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