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Article

A Cds1-mediated checkpoint protects the MBF activator Rep2 from ubiquitination by anaphase-promoting complex/cyclosome-Ste9 at S-phase arrest in fission yeast.

Molecular and cellular biology - 1 Sept 2009

Chu Zhaoqing, Eshaghi Majid, Poon Suk Yean, Liu Jianhua

Abstract excerpt

Transcription of the MluI cell cycle box (MCB) motif-containing genes at G(1) phase is regulated by the MCB-binding factors (MBF) (also called DSC1) in Schizosaccharomyces pombe. Upon S-phase arrest, the MBF transcriptional activity is induced through the accumulation of the MBF activator Rep2. In this study, we show that the turnover of Rep2 is attributable to ubiquitin-mediated proteolysis. Levels of Rep2...

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Source

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Identifiers

PMID: 19596787
DOI: 10.1128/MCB.00562-09
PMCID: PMC2738293

Genes

APC
DSC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Cds1-mediated checkpoint protects the MBF activator Rep2 from ubiquitination by anaphase-promoting complex/cyclosome-Ste9 at S-phase arrest in fission yeast.PMID 19596787Read ↗

A role for the START gene-specific transcription factor complex in the inactivation of cyclin B and Cut2 destruction.Semantic proximity Read ↗

An E2 enzyme Ubc11 is required for ubiquitination of Slp1/Cdc20 and spindle checkpoint silencing in fission yeast.Semantic proximity Read ↗

RCS1, a substrate of APC/C, controls the metaphase to anaphase transition.Semantic proximity Read ↗

The activity of S.pombe DSC-1-like factor is cell cycle regulated and dependent on the activity of p34cdc2.Semantic proximity Read ↗

DSC1-MCB regulation of meiotic transcription in Schizosaccharomyces pombe.Semantic proximity Read ↗

Cell cycle-regulated transcription in fission yeast: Cdc10-Res protein interactions during the cell cycle and domains required for regulated transcription.Semantic proximity Read ↗

The Schizosaccharomyces pombe MBF complex requires heterodimerization for entry into S phase.Semantic proximity Read ↗

Cds1 controls the release of Cdc14-like phosphatase Flp1 from the nucleolus to drive full activation of the checkpoint response to replication stress in fission yeast.Semantic proximity Read ↗

Fission yeast Mes1p ensures the onset of meiosis II by blocking degradation of cyclin Cdc13p.Semantic proximity Read ↗

Rsp1p, a J domain protein required for disassembly and assembly of microtubule organizing centers during the fission yeast cell cycle.Semantic proximity Read ↗

S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe.Semantic proximity Read ↗

The spike of S phase cyclin Cig2 expression at the G1-S border in fission yeast requires both APC and SCF ubiquitin ligases.Semantic proximity Read ↗

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