Article
Variants in candidate ALS modifier genes linked to Cu/Zn superoxide dismutase do not explain divergent survival phenotypes.
Neuroscience letters - 9 Jan 2006
Broom Wendy J, Russ Carsten, Sapp Peter C, McKenna-Yasek Diane, Hosler Betsy A, Andersen Peter M, Brown Robert H
Abstract excerpt
Familial amyotrophic lateral sclerosis (ALS) accounts for 10% of all ALS cases; approximately 25% are due to mutations in the Cu/Zn superoxide dismutase gene (SOD1). In North America, SOD1(A4V) is the most common SOD1 mutation. A4V ALS cases typically have a very short survival (1-1.5 years versus 3-5 years for other dominant SOD1 mutations). A recent study of A4V carriers identified a common haplotype around the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.