Article
SOD1A4V-mediated ALS: absence of a closely linked modifier gene and origination in Asia.
Neuroscience letters - 17 Jan 2008
Broom W J, Johnson D V, Auwarter K E, Iafrate A J, Russ C, Al-Chalabi A, Sapp P C, McKenna-Yasek D, Andersen P M, Brown R H
Abstract excerpt
Familial amyotrophic lateral sclerosis (ALS) accounts for 10% of all ALS. Approximately 20% of cases are due to mutations in the Cu/Zn superoxide dismutase gene (SOD1). In North America, SOD1(A4V) is the most common SOD1 mutation. Carriers of the SOD1(A4V) mutation share a common phenotype with rapid disease progression and death on average occurring at 1.4 years (versus 3-5 years with other dominant SOD1...
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