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Article

Individual Oligogenic Background in p.D91A-SOD1 Amyotrophic Lateral Sclerosis Patients.

Genes - 23 Nov 2021

Gentile Giulia, Perrone Benedetta, Morello Giovanna, Simone Isabella Laura, Andò Sebastiano, Cavallaro Sebastiano, Conforti Francesca Luisa

Abstract excerpt

The p.D91A is one of the most common ALS-causing SOD1 mutations and is known to be either recessive or dominant. The homozygous phenotype is characterized by prolonged survival and slow progression of disease, whereas the affected heterozygous phenotypes can vary. To date, no genetic protective factors located close to SOD1 have been associated with the mild progressive homozygous phenotype. Using Next Generation...

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Identifiers

PMID: 34946792
DOI: 10.3390/genes12121843
PMCID: PMC8701978

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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