[Preliminary exploration of transcription factor Nkx2.5 mutations and congenital heart diseases].

Abstract excerpt

OBJECTIVE: To explore the association between the gene mutation of transcription factor Nkx2.5 and Chinese patients with congenital heart disease (CHD). METHODS: Polymerase chain reaction (PCR) and DNA sequencing were used to check 99 CHD patients and 90 normal control subjects from the Zhong Da Hospital of Southeast University. After amplifying the exons 1 of the Nkx2.5 gene by PCR, we purified the PCR products...

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