Article
Genetic and functional analysis of the NKX2-5 gene promoter in patients with ventricular septal defects.
Pediatric cardiology - 1 Dec 2012
Pang Shuchao, Shan Jiping, Qiao Yanli, Ma Liming, Qin Xianyun, Wanyan Hongxin, Xing Qining, Wu Guanghua, Yan Bo
Abstract excerpt
The ventricular septal defect (VSD) is the most common type of congenital heart disease (CHD). The morbidity and mortality of CHD patients are significantly higher due to late cardiac complications, likely caused by genetic defects. Mutations in cardiac transcription factor genes such as GATA-4, TBX5, and NKX2-5 have been implicated in CHD cases. The NKX2-5 gene, a homeobox gene, is expressed in the developing...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.