Article
MICA gene polymorphism not associated with nonsyndromic cleft lip with or without cleft palate in the Japanese population?
Genetic testing and molecular biomarkers - 1 Aug 2009
Tamaki Shigehiro, Kawakami Masayoshi, Yamanaka Yasutsugu, Imai Yuichiro, Kawashima Wataru, Yamamoto Kazuhiko, Kasuda Shogo, Hatake Katsuhiko, Kirita Tadaaki
Abstract excerpt
UNLABELLED: Nonsyndromic cleft lip with or without cleft palate (NSCLP) is one of the most common birth defects. Despite its frequency, the etiology remains largely unknown. Most likely, both genetic and environmental factors contribute to this malformation. A polymorphic gene family, the major histocompatibility complex class I chain-related gene A (MICA), is located about 40 kb centromeric to the HLA-B gene. In...
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