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Article

Relative role of APC and MUTYH mutations in the pathogenesis of familial adenomatous polyposis.

Scandinavian journal of gastroenterology - 1 Jan 2009

Pezzi Annalisa, Roncucci Luca, Benatti Piero, Sassatelli Romano, Varesco Liliana, Di Gregorio Carmela, Venesio Tiziana, Pedroni Monica, Maffei Stefania, Reggiani Bonetti Luca, Borsi Enrica, Ferrari Maurizio, Martella Pietro, Rossi Giuseppina, Ponz De Leon Maurizio

Abstract excerpt

OBJECTIVE: Familial adenomatous polyposis (FAP) is an interesting model for the study of colorectal tumour. Two genes contribute to the FAP phenotype - APC and MUTYH - but their relative role is still undefined. The objective of this study was to evaluate the contribution of the two genes to the pathogenesis of FAP by means of a series of FAP families. MATERIAL AND METHODS: Sixty-one unrelated families with a...

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Source

Identifiers

PMID: 19593690
DOI: 10.1080/00365520903100481

Genes

MUTYH
APC
FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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