Contribution of APC and MUTYH mutations to familial adenomatous polyposis susceptibility in Hungary.

doi:10.1007/s10689-015-9845-5

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Article

Contribution of APC and MUTYH mutations to familial adenomatous polyposis susceptibility in Hungary.

Familial cancer - 1 Jan 2016

Papp Janos, Kovacs Marietta Eva, Matrai Zoltan, Orosz Enikő, Kásler Miklós, Børresen-Dale Anne-Lise, Olah Edith

Abstract excerpt

Familial adenomatous polyposis (FAP) is a colorectal cancer predisposition syndrome with considerable genetic and phenotypic heterogeneity, defined by the development of multiple adenomas throughout the colorectum. FAP is caused either by monoallelic mutations in the adenomatous polyposis coli gene APC, or by biallelic germline mutations of MUTYH, this latter usually presenting with milder phenotype. The aim of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26446593
DOI: 10.1007/s10689-015-9845-5
PMCID: PMC4698287

Genes

APC
FAP
MUTYH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.