Article
The genetics of familial adenomatous polyposis (FAP) and MutYH-associated polyposis (MAP).
Acta gastro-enterologica Belgica - 1 Sept 2011
Claes Kathleen, Dahan Karin, Tejpar S, De Paepe Anne, Bonduelle Maryse, Abramowicz Marc, Verellen Christine, Franchimont Denis, Van Cutsem Eric, Kartheuser Alex
Abstract excerpt
FAP is characterized by 100-1000s of adenomatous polyps in colon and rectum, and is in 70% of the patients associated with extracolonic manifestations. Attenuated FAP (AFAP) is a less severe form of FAP, marked by the presence of < 100 polyps and a later onset of colorectal cancer (CRC). (A)FAP is caused by autosomal dominantly inherited mutations in the APC (Adenomatous polyposis coli) gene, a tumour suppressor...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.