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Article

Integrin α6Bβ4 inhibits colon cancer cell proliferation and c-Myc activity

9 Jul 2009

Abstract excerpt

BACKGROUND: Integrins are known to be important contributors to cancer progression. We have previously shown that the integrin beta4 subunit is up-regulated in primary colon cancer. Its partner, the integrin alpha6 subunit, exists as two different mRNA splice variants, alpha6A and alpha6B, that differ in their cytoplasmic domains but evidence for distinct biological functions of these alpha6 splice variants is...

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PMID: 19586553
DOI: 10.1186/1471-2407-9-223

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