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Integrin α1β1 expression is controlled by c-MYC in colorectal cancer cells

22 Jun 2015

Abstract excerpt

The α1β1 collagen receptor is only present in a few epithelial cell types. In the intestine, it is specifically expressed in proliferating crypt cells. This integrin has been reported to be involved in various cancers where it mediates the downstream activation of the Ras/ERK proliferative pathway. We have recently shown that integrin α1β1 is present in two-thirds of colon adenocarcinomas, but the mechanism by...

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PMID: 26096932
DOI: 10.1038/onc.2015.231

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