Article
Organelle tethering by a homotypic PDZ interaction underlies formation of the Golgi membrane network.
The Journal of cell biology - 13 Jul 2009
Sengupta Debrup, Truschel Steven, Bachert Collin, Linstedt Adam D
Abstract excerpt
Formation of the ribbon-like membrane network of the Golgi apparatus depends on GM130 and GRASP65, but the mechanism is unknown. We developed an in vivo organelle tethering assaying in which GRASP65 was targeted to the mitochondrial outer membrane either directly or via binding to GM130. Mitochondria bearing GRASP65 became tethered to one another, and this depended on a GRASP65 PDZ domain that was also required...
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