Downregulation of peroxisome proliferator-activated receptor alpha and its coactivators in liver and skeletal muscle mediates the metabolic adaptations during lactation in mice.

Abstract excerpt

Previous studies have shown that genes involved in fatty acid uptake, fatty acid oxidation, and thermogenesis are downregulated in liver and skeletal muscle of rats during lactation. However, biochemical mechanisms underlying these important metabolic adaptations during lactation have not yet been elucidated. As all these genes are transcriptionally regulated by peroxisome proliferator-activated receptor alpha...

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