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Article

Maternal protein restriction impairs the transcriptional metabolic flexibility of skeletal muscle in adult rat offspring.

The British journal of nutrition - 14 Aug 2014

da Silva Aragão Raquel, Guzmán-Quevedo Omar, Pérez-García Georgina, Manhães-de-Castro Raul, Bolaños-Jiménez Francisco

Abstract excerpt

Skeletal muscle exhibits a remarkable flexibility in the usage of fuel in response to the nutrient intake and energy demands of the organism. In fact, increased physical activity and fasting trigger a transcriptional programme in skeletal muscle cells leading to a switch from carbohydrate to lipid oxidation. Impaired metabolic flexibility has been reported to be associated with obesity and type 2 diabetes, but it...

Topics

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AMP-Activated Protein Kinases
Carbohydrate Metabolism
Carnitine O-Palmitoyltransferase
Diet, Protein-Restricted
Fasting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

Uncoupling Protein 3

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Identifiers

PMID: 24823946
DOI: 10.1017/S0007114514000865

Genes

PGC
UCP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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