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Article

Disorders of sex development expose transcriptional autonomy of genetic sex and androgen-programmed hormonal sex in human blood leukocytes

1 Jan 2009

Abstract excerpt

BACKGROUND: Gender appears to be determined by independent programs controlled by the sex-chromosomes and by androgen-dependent programming during embryonic development. To enable experimental dissection of these components in the human, we performed genome-wide profiling of the transcriptomes of peripheral blood mononuclear cells (PBMC) in patients with rare defined "disorders of sex development" (DSD, e.g., 46,...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Sex and Gender in Healthcare

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 19570224
DOI: 10.1186/1471-2164-10-292

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