Article
A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22.
Arthritis and rheumatism - 1 Feb 2010
Kerkhof Hanneke J M, Lories Rik J, Meulenbelt Ingrid, Jonsdottir Ingileif, Valdes Ana M, Arp Pascal, Ingvarsson Thorvaldur, Jhamai Mila, Jonsson Helgi, Stolk Lisette, Thorleifsson Gudmar, Zhai Guangju, Zhang Feng, Zhu Yanyan, van der Breggen Ruud, Carr Andrew, Doherty Michael, Doherty Sally, Felson David T, Gonzalez Antonio, Halldorsson Bjarni V, Hart Deborah J, Hauksson Valdimar B, Hofman Albert, Ioannidis John P A, Kloppenburg Margreet, Lane Nancy E, Loughlin John, Luyten Frank P, Nevitt Michael C, Parimi Neeta, Pols Huibert A P, Rivadeneira Fernando, Slagboom Eline P, Styrkársdóttir Unnur, Tsezou Aspasia, van de Putte Tom, Zmuda Joseph, Spector Tim D, Stefansson Kari, Uitterlinden André G, van Meurs Joyce B J
Abstract excerpt
OBJECTIVE: To identify novel genes involved in osteoarthritis (OA), by means of a genome-wide association study. METHODS: We tested 500,510 single-nucleotide polymorphisms (SNPs) in 1,341 Dutch Caucasian OA cases and 3,496 Dutch Caucasian controls. SNPs associated with at least 2 OA phenotypes were analyzed in 14,938 OA cases and approximately 39,000 controls. Meta-analyses were performed using the program...
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