Article
Fancm-deficient mice reveal unique features of Fanconi anemia complementation group M.
Human molecular genetics - 15 Sept 2009
Bakker Sietske T, van de Vrugt Henri J, Rooimans Martin A, Oostra Anneke B, Steltenpool Jurgen, Delzenne-Goette Elly, van der Wal Anja, van der Valk Martin, Joenje Hans, te Riele Hein, de Winter Johan P
Abstract excerpt
The Fanconi anemia (FA) core complex member FANCM remodels synthetic replication forks and recombination intermediates. Thus far, only one FA patient with FANCM mutations has been described, but the relevance of these mutations for the FA phenotype is uncertain. To provide further experimental access to the FA-M complementation group we have generated Fancm-deficient mice by deleting exon 2. FANCM deficiency...
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