Article
Role of N-glycosylation of the SEA module of rodent Muc3 in posttranslational processing of its carboxy-terminal domain.
Glycobiology - 1 Oct 2009
He Yonghong, Li Yicheng, Peng Zhihong, Yu Hao, Zhang Xin, Chen Lei, Ji Qing, Chen Wensheng, Wang Rongquan
Abstract excerpt
A prominent feature of the rodent Muc3 SEA module is the precursor cleavage event that segregates the O-glycosylated N-terminal fragment and transmembrane domain into the noncovalently attached heterodimer. There are seven potential N-glycosylation sites that occur in a cluster in the SEA module of Muc3. However, it is unknown if these sites are modified or what the function of these N-glycans may be in the SEA...
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