Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mesenchymal to embryonic incomplete transition of human cells by chimeric OCT4/3 (POU5F1) with physiological co-activator EWS.

Experimental cell research - 1 Oct 2009

Makino Hatsune, Toyoda Masashi, Matsumoto Kenji, Saito Hirohisa, Nishino Koichiro, Fukawatase Yoshihiro, Machida Masakazu, Akutsu Hidenori, Uyama Taro, Miyagawa Yoshitaka, Okita Hajime, Kiyokawa Nobutaka, Fujino Takashi, Ishikawa Yuichi, Nakamura Takuro, Umezawa Akihiro

Abstract excerpt

POU5F1 (more commonly known as OCT4/3) is one of the stem cell markers, and affects direction of differentiation in embryonic stem cells. To investigate whether cells of mesenchymal origin acquire embryonic phenotypes, we generated human cells of mesodermal origin with overexpression of the chimeric OCT4/3 gene with physiological co-activator EWS (product of the EWSR1 gene), which is driven by the potent EWS...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mesoderm
Share to Mice, Inbred NOD

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, SCID

Share to Morphogenesis

Share to Octamer Transcription Factor-3

Share to Principal Component Analysis

Share to RNA-Binding Protein EWS

Share to Teratoma

Source

Identifiers

PMID: 19559696
DOI: 10.1016/j.yexcr.2009.06.016

Genes

EWSR1
NANOG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mesenchymal to embryonic incomplete transition of human cells by chimeric OCT4/3 (POU5F1) with physiological co-activator EWS.PMID 19559696Read ↗

Human mesenchymal stem cell transformation is associated with a mesenchymal–epithelial transitionSemantic proximity Read ↗

A logical model of Ewing sarcoma cell epithelial-to-mesenchymal transition supports the existence of hybrid cellular phenotypes.Semantic proximity Read ↗

Stimulation of Oct‐4 Activity by Ewing's Sarcoma ProteinSemantic proximity Read ↗

Role of the epithelial–mesenchymal transition and its effects on embryonic stem cellsSemantic proximity Read ↗

EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cells.Semantic proximity Read ↗

Common Expression of Stemness Molecular Markers and Early Cardiac Transcription Factors in Human Wharton's Jelly-Derived Mesenchymal Stem Cells and Embryonic Stem CellsSemantic proximity Read ↗

Human embryonic stem cell-derived mesoderm-like epithelium transitions to mesenchymal progenitor cells.Semantic proximity Read ↗

Embryonic Stem Cells Markers SOX2, OCT4 and Nanog Expression and Their Correlations with Epithelial-Mesenchymal Transition in Nasopharyngeal CarcinomaSemantic proximity Read ↗

POU5F1 Isoforms Show Different Expression Patterns in Human Embryonic Stem Cells and Preimplantation EmbryosSemantic proximity Read ↗

Fusion with mesenchymal stem cells differentially affects tumorigenic and metastatic abilities of lung cancer cellsSemantic proximity Read ↗

EWS-FLI1 Expression in Human Embryonic MSCs Leads to Transcriptional Reprograming, Defective DNA Damage Repair and Ewing SarcomaSemantic proximity Read ↗

Platypus Pou5f1 reveals the first steps in the evolution of trophectoderm differentiation and pluripotency in mammalsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.