Article
Fusion with mesenchymal stem cells differentially affects tumorigenic and metastatic abilities of lung cancer cells
11 Nov 2018
Abstract excerpt
Abstract Cell fusion plays a crucial role in cancer progression and leads to massive aberrant changes in chromosome and gene expression involved in tumor metastasis. Cancer cells can fuse with many cell types, including stromal cells, epithelial cells, macrophages, and endothelial cells. Mesenchymal stem cells (MSCs) have been reported to migrate and incorporate into tumor sites during cancer progression....
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