Article
A common UCP2 polymorphism predisposes to stress hyperglycaemia in severe sepsis.
Journal of medical genetics - 1 Nov 2009
Pyle A, Ibbett I M, Gordon C, Keers S M, Walker M, Chinnery P F, Baudouin S V
Abstract excerpt
BACKGROUND: Insulin resistance and hyperglycaemia are common in severe sepsis. Mitochondrial uncoupling protein 2 (UCP2) plays a role in insulin release and sensitivity. OBJECTIVES: To determine if a common, functional polymorphism in the UCP2 gene promoter region (the -866 G/A polymorphism) contributes to the risk of hyperglycaemia in severe sepsis. RESULTS: In the prospective group 120 non-diabetic patients who...
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