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Article

Synthesis and fungicidal activity of 3,5-dichloropyrazin-2(1H)-one derivatives.

Bioorganic & medicinal chemistry letters - 1 Aug 2009

François Isabelle E J A, Cammue Bruno P A, Bresseleers Sara, Fleuren Hein, Hoornaert Georges, Mehta Vaibhav P, Modha Sachin G, Van der Eycken Erik V, Thevissen Karin

Abstract excerpt

We synthesized a family of 3,5-dichloropyrazin-2(1H)-one derivatives and assessed their in vitro fungicidal activity against Candida albicans. Compounds 11 and 20 were most active against C. albicans and induced accumulation of reactive oxygen species in this pathogen. Using a genome-wide approach in the yeast Saccharomyces cerevisiae, we demonstrated that genes involved in vacuolar functionality and DNA-related...

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PMID: 19556127
DOI: 10.1016/j.bmcl.2009.06.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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