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Article

Genetic overlap between polycystic ovary syndrome and bipolar disorder: the endophenotype hypothesis.

Medical hypotheses - 1 Dec 2009

Jiang Bowen, Kenna Heather A, Rasgon Natalie L

Abstract excerpt

Polycystic Ovary Syndrome (PCOS) is a polygenic disorder caused by the interaction of susceptible genomic polymorphisms with environmental factors. PCOS, characterized by hyperandrogenism and menstrual abnormalities, has a higher prevalence in women with Bipolar Disorder (BD). Theories explaining this high prevalence have included the effect of PCOS itself or the effect of drugs such as Valproate, which may cause...

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Identifiers

PMID: 19556071
DOI: 10.1016/j.mehy.2008.12.056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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