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Article

Genomic relationship between polyendocrine metabolic ovarian syndrome and bipolar disorder.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Nov 2026

Jaholkowski Piotr, Tesfaye Markos, Fominykh Vera, Parekh Pravesh, Wiström Erik D, Parker Nadine, Koch Elise, Bauer Anna E, Trzaskoma Pawel, Rokicki Jaroslav, Bahrami Shahram, Rahman Zillur, Frei Oleksandr, Djurovic Srdjan, Dale Anders M, Shadrin Alexey A, O'Connell Kevin S, Andreassen Ole A

Abstract excerpt

Women with bipolar disorder (BIP) have a higher risk of developing polyendocrine metabolic ovarian syndrome (PMOS). Shared genetic architecture may underlie this comorbidity. Valproate, a mood-stabilizer commonly used to treat BIP, increases the risk of PMOS. Still, the mechanism underlying PMOS in BIP remains unknown. Here, we aimed to identify genetic variants shared between BIP and PMOS, as well as their...

Read the complete abstract on PubMed

Topics

Female
Humans
Bipolar Disorder
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Valproic Acid

Ovarian Diseases

Genetic Predisposition to Disease

Polymorphism, Single Nucleotide

Antimanic Agents

Genomics

Metabolic Diseases

Source

Identifiers

PMID: 42349268
DOI: 10.1016/j.euroneuro.2026.112903

Genes

CACNA1C
DCP1B
FDFT1
FKBP4
GATA4
NEIL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 27 Oct 2026.

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