Sex and strain differences in the circadian rhythm fluctuation of endocrine and immune function in the rat: implications for rodent models of autoimmune disease.

doi:10.1016/0165-5728(91)90161-y

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Article

Sex and strain differences in the circadian rhythm fluctuation of endocrine and immune function in the rat: implications for rodent models of autoimmune disease.

Journal of neuroimmunology - 1 Dec 1991

Griffin A C, Whitacre C C

Abstract excerpt

This study compares 24-h basal patterns of corticosterone and immunoreactivity for Lewis and Fischer (F344) strain rats. Significant differences in the circadian rhythm of plasma corticosterone were found across sex and strain. Male Lewis rats exhibited significantly lower 24-h corticosterone levels relative to female Lewis and male F344 rats. In addition, male Lewis rats were found to have higher mononuclear...

Topics

Animals
Autoimmune Diseases
Cell Count
Circadian Rhythm
Corticosterone
Disease Models, Animal
Endocrine Glands
Flow Cytometry
Immune System
Lymph Nodes
Lymphocyte Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocytes

Male

Mitogens

Monocytes

Phenotype

Rats

Rats, Inbred F344

Source

Open in PubMed

Identifiers

PMID: 1955572
DOI: 10.1016/0165-5728(91)90161-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1955572-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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