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Article

OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism.

Journal of molecular medicine (Berlin, Germany) - 1 Aug 2009

Perttilä Julia, Merikanto Krista, Naukkarinen Jussi, Surakka Ida, Martin Nicolas W, Tanhuanpää Kimmo, Grimard Vinciane, Taskinen Marja-Riitta, Thiele Christoph, Salomaa Veikko, Jula Antti, Perola Markus, Virtanen Ismo, Peltonen Leena, Olkkonen Vesa M

Abstract excerpt

Analysis of variants in three genes encoding oxysterol-binding protein (OSBP) homologues (OSBPL2, OSBPL9, OSBPL10) in Finnish families with familial low high-density lipoprotein (HDL) levels (N = 426) or familial combined hyperlipidemia (N = 684) revealed suggestive linkage of OSBPL10 single-nucleotide polymorphisms (SNPs) with extreme end high triglyceride (TG; >90th percentile) trait. Prompted by this initial...

Topics

Cell Line, Tumor
Cholesterol, HDL
Female
Finland
Gene Silencing
Hepatocytes
Humans
Hyperlipidemia, Familial Combined
Lipid Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Microtubules

Polymorphism, Single Nucleotide

Receptors, Steroid

Triglycerides

Oxysterol Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19554302
DOI: 10.1007/s00109-009-0490-z
PMCID: PMC2707950

Genes

OSBPL10
OSBP
OSBPL2
OSBPL9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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