Article
OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism.
Journal of molecular medicine (Berlin, Germany) - 1 Aug 2009
Perttilä Julia, Merikanto Krista, Naukkarinen Jussi, Surakka Ida, Martin Nicolas W, Tanhuanpää Kimmo, Grimard Vinciane, Taskinen Marja-Riitta, Thiele Christoph, Salomaa Veikko, Jula Antti, Perola Markus, Virtanen Ismo, Peltonen Leena, Olkkonen Vesa M
Abstract excerpt
Analysis of variants in three genes encoding oxysterol-binding protein (OSBP) homologues (OSBPL2, OSBPL9, OSBPL10) in Finnish families with familial low high-density lipoprotein (HDL) levels (N = 426) or familial combined hyperlipidemia (N = 684) revealed suggestive linkage of OSBPL10 single-nucleotide polymorphisms (SNPs) with extreme end high triglyceride (TG; >90th percentile) trait. Prompted by this initial...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.