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Article

Sterol binding by OSBP-related protein 1L regulates late endosome motility and function.

Cellular and molecular life sciences : CMLS - 1 Feb 2011

Vihervaara Terhi, Uronen Riikka-Liisa, Wohlfahrt Gerd, Björkhem Ingemar, Ikonen Elina, Olkkonen Vesa M

Abstract excerpt

ORP1L is an oxysterol binding homologue that regulates late endosome (LE) positioning. We show that ORP1L binds several oxysterols and cholesterol, and characterize a mutant, ORP1L Δ560-563, defective in oxysterol binding. While wild-type ORP1L clusters LE, ORP1L Δ560-563 induces LE scattering, which is reversed by disruption of the endoplasmic reticulum (ER) targeting FFAT motif, suggesting that it is due to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20690035
DOI: 10.1007/s00018-010-0470-z
PMCID: PMC11114714

Genes

EGF
OSBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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