Article
Common germline polymorphisms in COMT, CYP19A1, ESR1, PGR, SULT1E1 and STS and survival after a diagnosis of breast cancer.
International journal of cancer - 1 Dec 2009
Udler Miriam S, Azzato Elizabeth M, Healey Catherine S, Ahmed Shahana, Pooley Karen A, Greenberg David, Shah Mitul, Teschendorff Andrew E, Caldas Carlos, Dunning Alison M, Ostrander Elaine A, Caporaso Neil E, Easton Douglas, Pharoah Paul D
Abstract excerpt
Although preliminary evidence suggests that germline variation in genes involved in steroid hormone metabolism may alter breast cancer prognosis, this has not been systematically evaluated. We examined associations between germline polymorphisms in 6 genes involved in the steroid hormone metabolism and signaling pathway (COMT, CYP19A1, ESR1, PGR, SULT1E1, STS) and survival among women with breast cancer...
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