Article
DNA methylation represses IFN-gamma-induced and signal transducer and activator of transcription 1-mediated IFN regulatory factor 8 activation in colon carcinoma cells.
Molecular cancer research : MCR - 1 Dec 2008
McGough Jon M, Yang Dafeng, Huang Shuang, Georgi David, Hewitt Stephen M, Röcken Christoph, Tänzer Marc, Ebert Matthias P A, Liu Kebin
Abstract excerpt
IFN regulatory factor 8 (IRF8) is both constitutively expressed and IFN-gamma inducible in hematopoietic and nonhematopoietic cells. We have shown that IRF8 expression is silenced by DNA methylation in human colon carcinoma cells, but the molecular mechanism underlying methylation-dependent IRF8 silencing remains elusive. In this study, we observed that IRF8 protein level is inversely correlated with the...
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