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Article

Inhibitory effect of wild-type p53 gene on excessive replication of centrosomes in leukemia cell line K562.

Ai zheng = Aizheng = Chinese journal of cancer - 1 Feb 2009

Tian Wen-Jun, Feng Wen-Li, Wang Hong-Bin, Huang Shi-Feng, Cao Wei-Xi, Huang Zong-Gan

Abstract excerpt

BACKGROUND AND OBJECTIVE: Mutation and deletion of the p53 gene in tumor cells is one of the major reasons for aneuploid development and genomic instability. Abnormal centrosomes exist in chronic myelogenous leukemia patients at different stages; furthermore, the degree of abnormality is associated with the clinical stage and more severe in the blast crisis stage. This study was to establish the leukemia cell...

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PMID: 19550118

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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