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Article

Breast cancer migration and invasion depend on proteasome degradation of regulator of G-protein signaling 4.

Cancer research - 15 Jul 2009

Xie Yan, Wolff Dennis W, Wei Taotao, Wang Bo, Deng Caishu, Kirui Joseph K, Jiang Haihong, Qin Jianbing, Abel Peter W, Tu Yaping

Abstract excerpt

Aberrant signaling through G-protein coupled receptors promotes metastasis, the major cause of breast cancer death. We identified regulator of G-protein signaling 4 (RGS4) as a novel suppressor of breast cancer migration and invasion, important steps of metastatic cascades. By blocking signals initiated through G(i)-coupled receptors, such as protease-activated receptor 1 and CXC chemokine receptor 4, RGS4...

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Source

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Identifiers

PMID: 19549919
DOI: 10.1158/0008-5472.CAN-08-3564
PMCID: PMC2741027

Genes

RGS4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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