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Article

Regulator of G protein signaling 6 is a novel suppressor of breast tumor initiation and progression

18 Apr 2013

Abstract excerpt

Breast cancer is a large global health burden and the most frequently diagnosed malignancy in women worldwide. Here, we utilize RGS6(-/-) mice to interrogate the role of regulator of G protein signaling 6 (RGS6), localized to the ductal epithelium in mouse and human breast, as a novel tumor suppressor in vivo. RGS6(-/-) mice exhibit accelerated 7,12-dimethylbenza[α]anthracene (DMBA)-induced tumor initiation and...

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PMID: 23598467
DOI: 10.1093/carcin/bgt128

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