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MGMT Immunohistochemical Expression and Promoter Methylation in Human Glioblastoma

1 Jan 2008

Abstract excerpt

O6-methylguanine-DNA methyltransferase (MGMT) expression has been recently proposed as a useful prognostic and/or predictive marker in glioblastoma patients receiving adjuvant therapy after the surgery. We studied samples from 50 patients with histologically confirmed GBM to evaluate MGMT expression by immunohistochemistry and its relation to promoter methylation status. Genomic DNA was extracted from scrapings...

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PMID: 18091318
DOI: 10.1097/pai.0b013e31802fac2f

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