Article
Analysis of mutations in TP53, APC, K-ras, and DCC genes in the non-dysplastic mucosa of patients with inflammatory bowel disease.
International journal of colorectal disease - 1 Oct 2009
Rapozo Davy Carlos Mendes, Grinmann Ana Braunstein, Carvalho Ana Teresa Pugas, de Souza Heitor Siffert P, Soares-Lima Sheila Coelho, de Almeida Simão Tatiana, de Paiva Daurita, Abby Flávio, Albano Rodolpho Mattos, Pinto Luiz Felipe Ribeiro
Abstract excerpt
BACKGROUND AND AIMS: Patients with ulcerative colitis (UC) and Crohn's disease (CD) have a high risk for colorectal cancer (CRC). To understand the molecular basis of colitis-associated CRC, we analyzed alterations in TP53, APC, K-ras, and DCC genes in the non-dysplastic UC and CD colon. MATERIALS AND METHODS: Endoscopic biopsies were collected from six predefined colon sites of 35 UC and 12 CD patients for DNA...
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