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Article

A unique glucose-dependent apoptotic pathway induced by c-Myc

17 Feb 1998

Abstract excerpt

The lactate dehydrogenase A (LDH-A) gene, whose product participates in normal anaerobic glycolysis and is frequently increased in human cancers, has been identified as a c-Myc-responsive gene. It was of interest, therefore, to compare the effect of glucose deprivation in c-Myc-transformed and nontransformed cells. We observed that glucose deprivation or treatment with the glucose antimetabolite 2-deoxyglucose...

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PMID: 9465046
DOI: 10.1073/pnas.95.4.1511

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