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Article

Multiplex detection of 60 hepatitis B virus variants by maldi-tof mass spectrometry.

Clinical chemistry - 1 Aug 2009

Luan Ju, Yuan Jing, Li Xiaohe, Jin Shengnan, Yu Ling, Liao Mingfeng, Zhang Hongmei, Xu Cheng, He Qing, Wen Bin, Zhong Xunhua, Chen Xinchun, Chan Henry L Y, Sung Joseph J Y, Zhou Boping, Ding Chunming

Abstract excerpt

BACKGROUND: Variations in the hepatitis B virus (HBV) genome may develop spontaneously or under selective pressure from antiviral therapy. Such variations may confer drug resistance or affect virus replication capacity, resulting in failure of antiviral therapy. METHODS: A duplex PCR was used to amplify the region of the reverse transcriptase gene, the precore promoter, and the basal core promoter of the HBV...

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Share to DNA, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genome, Viral

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Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Source

Identifiers

PMID: 19541863
DOI: 10.1373/clinchem.2009.124859

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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