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Article

Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder.

American journal of human genetics - 1 Jul 2009

Holmans Peter, Green Elaine K, Pahwa Jaspreet Singh, Ferreira Manuel A R, Purcell Shaun M, Sklar Pamela, Owen Michael J, O'Donovan Michael C, Craddock Nick

Abstract excerpt

We present a method for testing overrepresentation of biological pathways, indexed by gene-ontology terms, in lists of significant SNPs from genome-wide association studies. This method corrects for linkage disequilibrium between SNPs, variable gene size, and multiple testing of nonindependent pathways. The method was applied to the Wellcome Trust Case-Control Consortium Crohn disease (CD) data set. At a general...

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Identifiers

PMID: 19539887
DOI: 10.1016/j.ajhg.2009.05.011
PMCID: PMC2706963

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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