Article
Genome-wide association studies: progress and potential for drug discovery and development.
Nature reviews. Drug discovery - 1 Mar 2008
Kingsmore Stephen F, Lindquist Ingrid E, Mudge Joann, Gessler Damian D, Beavis William D
Abstract excerpt
Although genetic studies have been critically important for the identification of therapeutic targets in Mendelian disorders, genetic approaches aiming to identify targets for common, complex diseases have traditionally had much more limited success. However, during the past year, a novel genetic approach - genome-wide association (GWA) - has demonstrated its potential to identify common genetic variants...
Topics
- Diabetes Mellitus
- Drug Design
- Genetic Predisposition to Disease
- Genome, Human
- Humans
- Inflammatory Bowel Diseases
- Neoplasms