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Article

Complex T Cell Interactions Contribute to Helicobacter pylori Gastritis in Mice

22 Dec 2012

Abstract excerpt

Disease due to the gastric pathogen Helicobacter pylori varies in severity from asymptomatic to peptic ulcer disease and cancer. Accumulating evidence suggests that one source of this variation is an abnormal host response. The goal of this study was to use a mouse model of H. pylori gastritis to investigate the roles of regulatory T cells (Treg) as well as proinflammatory T cells (Th1 and Th17) in gastritis,...

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PMID: 23264048
DOI: 10.1128/iai.01269-12

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