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PLEKHH2 binds β-arrestin1 through its FERM domain, activates FAK/PI3K/AKT phosphorylation, and promotes the malignant phenotype of non-small cell lung cancer.

Cell death & disease - 8 Oct 2022

Wang Rui, Wang Si, Li Zhen, Luo Yuan, Zhao Yue, Han Qiang, Rong Xue-Zhu, Guo Yao-Xing, Liu Yang

Abstract excerpt

PLEKHH2 is an important FERM domain containing-protein. However, the role of PLEKHH2 in human solid tumors has not been reported yet. We report that PLEKHH2 showed enhanced cytoplasmic expression in non-small cell lung cancer (NSCLC). Its overexpression was positively correlated with high TNM stage, low differentiation, lymphatic node metastasis, and poor prognosis. In A549 and H1299 cells, high expression of...

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PMID: 36209201
DOI: 10.1038/s41419-022-05307-5
PMCID: PMC9547923

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