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Article

miR-203 Regulates Cell Proliferation through Its Influence on Hakai Expression

20 Dec 2012

Abstract excerpt

Gene expression is potently regulated through the action of microRNAs (miRNAs). Here, we present evidence of a miRNA regulating Hakai protein. Hakai was discovered as an E3 ubiquitin-ligase that mediates the posttranslational downregulation of E-cadherin, a major component of adherens junctions in epithelial cells and a potent tumour suppressor. Recent data have provided evidence that Hakai affects cell...

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PMID: 23285092
DOI: 10.1371/journal.pone.0052568

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