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Genetics of Chromosomally Mediated Intermediate Resistance to Ceftriaxone and Cefixime in <i>Neisseria gonorrhoeae</i>

15 Jun 2009

Abstract excerpt

All strains of Neisseria gonorrhoeae with reduced susceptibility to ceftriaxone and cefixime (cephalosporin-intermediate-resistant [Ceph(i)] strains) contain a mosaic penA allele encoding penicillin-binding protein 2 (PBP 2) with nearly 60 amino acid differences compared to the sequence of wild-type PBP 2, together with a set of resistance determinants (i.e., mtrR, penB, and/or ponA1) that are required for...

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PMID: 19528266
DOI: 10.1128/aac.00304-09

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Genetics of Chromosomally Mediated Intermediate Resistance to Ceftriaxone and Cefixime in <i>Neisseria gonorrhoeae</i>PMID 19528266Read ↗

Spread of a Chromosomal Cefixime-Resistant <i>penA</i> Gene among Different <i>Neisseria gonorrhoeae</i> LineagesSemantic proximity Read ↗

Mosaic-Like Structure of Penicillin-Binding Protein 2 Gene ( <i>penA</i> ) in Clinical Isolates of <i>Neisseria gonorrhoeae</i> with Reduced Susceptibility to CefiximeSemantic proximity Read ↗

Mutations in ponA, the gene encoding penicillin-binding protein 1, and a novel locus, penC, are required for high-level chromosomally mediated penicillin resistance in Neisseria gonorrhoeae.Semantic proximity Read ↗

Amino Acid Substitutions in Mosaic Penicillin-Binding Protein 2 Associated with Reduced Susceptibility to Cefixime in Clinical Isolates of <i>Neisseria gonorrhoeae</i>Semantic proximity Read ↗

The role of the L421P mutation in Penicillin-Binding Protein 1 (PBP1) in the evolution of chromosomally mediated penicillin resistance in <i>Neisseria gonorrhoeae</i>Semantic proximity Read ↗

A Case of Decreased Susceptibility to Ceftriaxone in Neisseria gonorrhoeae in the Absence of a Mosaic Penicillin-Binding Protein 2 (penA) Allele.Semantic proximity Read ↗

Reduced susceptibility to ceftriaxone in Neisseria gonorrhoeae is associated with mutations G542S, P551S and P551L in the gonococcal penicillin-binding protein 2Semantic proximity Read ↗

Molecular and structural analysis of mosaic variants of penicillin-binding protein 2 conferring decreased susceptibility to expanded-spectrum cephalosporins in Neisseria gonorrhoeae: role of epistatic mutations.Semantic proximity Read ↗

Antibiotic-resistance mutations in penicillin-binding protein 2 from the ceftriaxone-resistant Neisseria gonorrhoeae strain H041 strike a delicate balance between increasing resistance and maintaining transpeptidase activity.Semantic proximity Read ↗

Analysis of mutations within multiple genes associated with resistance in a clinical isolate of Neisseria gonorrhoeae with reduced ceftriaxone susceptibility that shows a multidrug-resistant phenotype.Semantic proximity Read ↗

Identification of amino acids conferring high-level resistance to expanded-spectrum cephalosporins in the penA gene from Neisseria gonorrhoeae strain H041.Semantic proximity Read ↗

Various penA mutations together with mtrR, porB and ponA mutations in Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime or ceftriaxone.Semantic proximity Read ↗

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