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Mosaic-Like Structure of Penicillin-Binding Protein 2 Gene ( <i>penA</i> ) in Clinical Isolates of <i>Neisseria gonorrhoeae</i> with Reduced Susceptibility to Cefixime

15 Nov 2002

Abstract excerpt

Neisseria gonorrhoeae strains with reduced susceptibility to cefixime (MICs, 0.25 to 0.5 micro g/ml) were isolated from male urethritis patients in Tokyo, Japan, in 2000 and 2001. The resistance to cephems including cefixime and penicillin was transferred to a susceptible recipient, N. gonorrhoeae ATCC 19424, by transformation of the penicillin-binding protein 2 gene (penA) that had been amplified by PCR from a...

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PMID: 12435671
DOI: 10.1128/aac.46.12.3744-3749.2002

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