Article
Importance of nuclear localization for the apoptosis-induced activity of a fungal galectin AAL (Agrocybe aegerita lectin).
Biochemical and biophysical research communications - 28 Aug 2009
Liang Yi, Feng Lei, Tong Xin, Wang Kun, Li De Feng, Lin Jia Cheng, Tang Zi Jian, Liu Hong Hong, Jiang Shuai, Guo Lin, Wang Da Cheng, Sun Hui
Abstract excerpt
Agrocybe aegerita lectin (AAL) was identified previously in our group as a novel galectin from medicinal fungi Agrocybe aegerita, and has been shown to effectively induce cancer cell cycle arrest and apoptosis in vitro and tumor regression in vivo. Here, AAL was observed to translocate into the HeLa cell nucleus and induce cell apoptosis when it was predominantly in the nucleus. The N-terminus and C-terminus of...
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